Leishmania-Induced Inactivation of the Macrophage Transcription Factor AP-1 Is Mediated by the Parasite Metalloprotease GP63

Leishmania parasites have evolved sophisticated mechanisms to subvert macrophage immune responses by altering the host cell signal transduction machinery, including inhibition of JAK/STAT signalling and other transcription factors such as AP-1, CREB and NF-κB. AP-1 regulates pro-inflammatory cytokin...

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Главные авторы: Contreras, Irazú, Gómez, María Adelaida, Nguyen, Oliver, Shio, Marina T., McMaster, Robert W., Olivier, Martin
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2010
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2954837/
https://ncbi.nlm.nih.gov/pubmed/20976196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1001148
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