Gimap3 Regulates Tissue-Specific Mitochondrial DNA Segregation

Mitochondrial DNA (mtDNA) sequence variants segregate in mutation and tissue-specific manners, but the mechanisms remain unknown. The segregation pattern of pathogenic mtDNA mutations is a major determinant of the onset and severity of disease. Using a heteroplasmic mouse model, we demonstrate that...

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Detalhes bibliográficos
Main Authors: Jokinen, Riikka, Marttinen, Paula, Sandell, Helen Katarin, Manninen, Tuula, Teerenhovi, Heli, Wai, Timothy, Teoli, Daniella, Loredo-Osti, J. C., Shoubridge, Eric A., Battersby, Brendan J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2954831/
https://ncbi.nlm.nih.gov/pubmed/20976251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1001161
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