Inhibition of cytoplasmic and organellar protein synthesis in Toxoplasma gondii. Implications for the target of macrolide antibiotics.

We investigated potential targets for the activity of protein synthesis inhibitors against the protozoan parasite Toxoplasma gondii. Although nanomolar concentrations of azithromycin and clindamycin prevent replication of T. gondii in both cell culture and in vivo assays, no inhibition of protein la...

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Bibliographic Details
Main Authors: Beckers, C J, Roos, D S, Donald, R G, Luft, B J, Schwab, J C, Cao, Y, Joiner, K A
Format: Artigo
Language:Inglês
Published: 1995
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC295440/
https://ncbi.nlm.nih.gov/pubmed/7814637
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