Recapitulation of normal and abnormal BB rat immune system development in scid mouse/rat lymphohemopoietic chimeras.

Mice homozygous for the mutation "severe combined immune deficiency" (C.B17-scid/scid) lack functional T and B lymphocytes and readily accept tumor xenografts. Partial lymphohemopoietic scid/human and mouse/rat chimeras have been described, but complete chimerization with thymic engraftment and gene...

Полное описание

Библиографические подробности

Опубликовано в::	J Clin Invest
Главные авторы:	Greiner, D L, Shultz, L D, Rossini, A A, Mordes, J P, Handler, E S, Rajan, T V
Формат:	Artigo
Язык:	Inglês
Опубликовано:	American Society for Clinical Investigation 1991
Предметы:	Research Article
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC295424/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1864981/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI115359
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