MAP1B Regulates Axonal Development by Modulating Rho-GTPase Rac1 Activity

Cultured neurons obtained from MAP1B-deficient mice have a delay in axon outgrowth and a reduced rate of axonal elongation compared with neurons from wild-type mice. Here we show that MAP1B deficiency results in a significant decrease in Rac1 and cdc42 activity and a significant increase in Rho acti...

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Main Authors: Montenegro-Venegas, Carolina, Tortosa, Elena, Rosso, Silvana, Peretti, Diego, Bollati, Flavia, Bisbal, Mariano, Jausoro, Ignacio, Avila, Jesus, Cáceres, Alfredo, Gonzalez-Billault, Christian
Format: Artigo
Language:Inglês
Published: The American Society for Cell Biology 2010
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2954117/
https://ncbi.nlm.nih.gov/pubmed/20719958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E09-08-0709
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