Evidence for enhanced vascular superoxide anion production in nitrate tolerance. A novel mechanism underlying tolerance and cross-tolerance.

We sought to examine mechanisms underlying nitroglycerin (NTG) tolerance and "cross-tolerance" to other nitrovasodilators. Rabbits were treated for 3 d with NTG patches (0.4 mg/h) and their aortic segments studied in organ chambers. Relaxations were examined after preconstriction with phen...

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Detaylı Bibliyografya
Yayımlandı:J Clin Invest
Asıl Yazarlar: Münzel, T, Sayegh, H, Freeman, B A, Tarpey, M M, Harrison, D G
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Clinical Investigation 1995
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC295403/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7814613/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI117637
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