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Intravenously injected insulin-like growth factor (IGF) I/IGF binding protein-3 complex exerts insulin-like effects in hypophysectomized, but not in normal rats.

Insulin-like growth factor (IGF) circulates in blood in two large molecular mass forms of 150 and 40 kD. Under normal conditions, most of the IGF is bound to the 150-kD complex by which it is retained in the circulation and therefore unable to exert acute insulin-like actions. The aim of this study...

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Udgivet i:J Clin Invest
Principais autores: Zapf, J, Hauri, C, Futo, E, Hussain, M, Rutishauser, J, Maack, C A, Froesch, E R
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 1995
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC295401/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7529258/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI117636
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