Sustained IL-4 exposure leads to a novel pathway for hemophagocytosis, inflammation, and tissue macrophage accumulation

Erythrophagocytosis and inflammation from activated macrophages occur in distinct clinical scenarios. The presence of CD8(+) T cells and interferon-γ (IFN-γ) production is required to induce disease in mouse models of hemophagocytic lymphohistiocytosis. We investigated the roles of a different class...

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Autores principales: Milner, Joshua D., Orekov, Tatyana, Ward, Jerrold M., Cheng, Lily, Torres-Velez, Fernando, Junttila, Ilkka, Sun, Guangping, Buller, Mark, Morris, Suzanne C., Finkelman, Fred D., Paul, William E.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2010
Materias:
Immunobiology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2953884/
https://ncbi.nlm.nih.gov/pubmed/20570861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-11-255174
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