Dissolution of arterial platelet thrombi in vivo with a bifunctional platelet GPIIIa49-66 ligand which specifically targets the platelet thrombus

Patients with HIV-1 immune-related thrombocytopenia have a unique antibody (Ab) against integrin GPIIIa49-66 capable of inducing oxidative platelet fragmentation via Ab activation of platelet nicotinamide adenine dinucleotide phosphate oxidase and 12-lipoxygenase releasing reactive oxygen species. U...

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Autors principals: Zhang, Wei, Li, Yong-Sheng, Nardi, Michael A., Dang, Suying, Yang, Jing, Ji, Yong, Li, Zongdong, Karpatkin, Simon, Wisniewski, Thomas
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2010
Matèries:
Platelets and Thrombopoiesis
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2953838/
https://ncbi.nlm.nih.gov/pubmed/20525921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-01-264358
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