Reproducing abnormal cholesterol biosynthesis as seen in the Smith-Lemli-Opitz syndrome by inhibiting the conversion of 7-dehydrocholesterol to cholesterol in rats.

Gelijkaardige items

• Markedly inhibited 7-dehydrocholesterol-delta 7-reductase activity in liver microsomes from Smith-Lemli-Opitz homozygotes.
  door: Shefer, S, et al.
  Gepubliceerd in: (1995)
• 7-Dehydrocholesterol–dependent proteolysis of HMG-CoA reductase suppresses sterol biosynthesis in a mouse model of Smith-Lemli-Opitz/RSH syndrome
  door: Fitzky, Barbara U., et al.
  Gepubliceerd in: (2001)
• Lathosterolosis: A Disorder of Cholesterol Biosynthesis Resembling Smith-Lemli-Opitz Syndrome
  door: Ho, A. C. C., et al.
  Gepubliceerd in: (2013)
• Comparison of the liquid-ordered bilayer phases containing cholesterol or 7-dehydrocholesterol in modeling Smith-Lemli-Opitz syndrome
  door: Staneva, Galya, et al.
  Gepubliceerd in: (2010)
• Smith-Lemli-Opitz syndrome is caused by mutations in the 7-dehydrocholesterol reductase gene.
  door: Waterham, H R, et al.
  Gepubliceerd in: (1998)