Porcine Reproductive and Respiratory Syndrome Virus Inhibits Type I Interferon Signaling by Blocking STAT1/STAT2 Nuclear Translocation

Type I interferons (IFNs) IFN-α/β play an important role in innate immunity against viral infections by inducing antiviral responses. Porcine reproductive and respiratory syndrome virus (PRRSV) inhibits the synthesis of type I IFNs. However, whether PRRSV can inhibit IFN signaling is less well under...

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Detalhes bibliográficos
Main Authors: Patel, Deendayal, Nan, Yuchen, Shen, Meiyan, Ritthipichai, Krit, Zhu, Xiaoping, Zhang, Yan-Jin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2953160/
https://ncbi.nlm.nih.gov/pubmed/20739522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00655-10
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