Lambda Interferon Is the Predominant Interferon Induced by Influenza A Virus Infection In Vivo

The type I alpha/beta interferons (IFN-α/β) are known to play an important role in host defense against influenza A virus infection, but we have now discovered that the recently identified type III IFNs (IFN-λ) constitute the major response to intranasal infection with this virus. Type III IFNs were...

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Detalhes bibliográficos
Main Authors: Jewell, Nancy A., Cline, Troy, Mertz, Sara E., Smirnov, Sergey V., Flaño, Emilio, Schindler, Christian, Grieves, Jessica L., Durbin, Russell K., Kotenko, Sergei V., Durbin, Joan E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2953143/
https://ncbi.nlm.nih.gov/pubmed/20739515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01703-09
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