Effects of the PPARα Agonist and Widely Used Antihyperlipidemic Drug Gemfibrozil on Hepatic Toxicity and Lipid Metabolism

Gemfibrozil is a widely prescribed hypolipidemic agent in humans and a peroxisome proliferator and liver carcinogen in rats. Three-month feed studies of gemfibrozil were conducted by the National Toxicology Program (NTP) in male Harlan Sprague-Dawley rats, B6C3F1 mice, and Syrian hamsters, primarily...

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Detalhes bibliográficos
Main Authors: Cunningham, Michael L., Collins, Bradley J., Hejtmancik, Milton R., Herbert, Ronald A., Travlos, Gregory S., Vallant, Molly K., Stout, Matthew D.
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2952818/
https://ncbi.nlm.nih.gov/pubmed/20953357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2010/681963
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