Isolation of SPINK6 in Human Skin: SELECTIVE INHIBITOR OF KALLIKREIN-RELATED PEPTIDASES

Kallikrein-related peptidases (KLKs) play a central role in skin desquamation. They are tightly controlled by specific inhibitors, including the lymphoepithelial Kazal-type inhibitor (LEKTI) encoded by SPINK5 and LEKTI-2 encoded by SPINK9. Herein, we identify SPINK6 as a selective inhibitor of KLKs...

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Bibliografiske detaljer
Main Authors: Meyer-Hoffert, Ulf, Wu, Zhihong, Kantyka, Tomasz, Fischer, Jan, Latendorf, Ties, Hansmann, Britta, Bartels, Joachim, He, Yinghong, Gläser, Regine, Schröder, Jens-Michael
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2010
Fag:
Protein Synthesis and Degradation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2952218/
https://ncbi.nlm.nih.gov/pubmed/20667819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.091850
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