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A New Kv1.2 Channelopathy Underlying Cerebellar Ataxia
A forward genetic screen of mice treated with the mutagen ENU identified a mutant mouse with chronic motor incoordination. This mutant, named Pingu (Pgu), carries a missense mutation, an I402T substitution in the S6 segment of the voltage-gated potassium channel Kcna2. The gene Kcna2 encodes the vol...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2952217/ https://ncbi.nlm.nih.gov/pubmed/20696761 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.153676 |
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