A New Kv1.2 Channelopathy Underlying Cerebellar Ataxia

A forward genetic screen of mice treated with the mutagen ENU identified a mutant mouse with chronic motor incoordination. This mutant, named Pingu (Pgu), carries a missense mutation, an I402T substitution in the S6 segment of the voltage-gated potassium channel Kcna2. The gene Kcna2 encodes the vol...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Xie, Gang, Harrison, John, Clapcote, Steven J., Huang, Yun, Zhang, Jin-Yi, Wang, Lu-Yang, Roder, John C.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2010
Fag:
Neurobiology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2952217/
https://ncbi.nlm.nih.gov/pubmed/20696761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.153676
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker