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A New Kv1.2 Channelopathy Underlying Cerebellar Ataxia

A forward genetic screen of mice treated with the mutagen ENU identified a mutant mouse with chronic motor incoordination. This mutant, named Pingu (Pgu), carries a missense mutation, an I402T substitution in the S6 segment of the voltage-gated potassium channel Kcna2. The gene Kcna2 encodes the vol...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Xie, Gang, Harrison, John, Clapcote, Steven J., Huang, Yun, Zhang, Jin-Yi, Wang, Lu-Yang, Roder, John C.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2010
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2952217/
https://ncbi.nlm.nih.gov/pubmed/20696761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.153676
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