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Urate crystals stimulate production of tumor necrosis factor alpha from human blood monocytes and synovial cells. Cytokine mRNA and protein kinetics, and cellular distribution.

Crystals of monosodium urate (MSU) provide a dose-dependent stimulus for the production by human blood monocytes of tumor necrosis factor (TNF), a cytokine with proinflammatory properties; TNF activity was inhibited selectively by monoclonal antibody to TNF alpha. Biologically active cell-associated...

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Sonraí Bibleagrafaíochta
Main Authors: di Giovine, F S, Malawista, S E, Thornton, E, Duff, G W
Formáid: Artigo
Teanga:Inglês
Foilsithe: 1991
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC295177/
https://ncbi.nlm.nih.gov/pubmed/2010550
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