Evidence for direct local effect of angiotensin in vascular hypertrophy. In vivo gene transfer of angiotensin converting enzyme.

In vitro studies have demonstrated that angiotensin (Ang) II directly stimulates vascular smooth muscle cell (VSMC) growth. However, it is still unclear if Ang II exerts a direct effect on vascular hypertrophy in vivo independent of its effect on blood pressure. In vivo gene transfer provides the op...

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Pubblicato in:	J Clin Invest
Autori principali:	Morishita, R, Gibbons, G H, Ellison, K E, Lee, W, Zhang, L, Yu, H, Kaneda, Y, Ogihara, T, Dzau, V J
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 1994
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC295142/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8083382/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI117464
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