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Polymorphic genetic control of tumor invasion in a mouse model of pancreatic neuroendocrine carcinogenesis

Cancer is a disease subject to both genetic and environmental influences. In this study, we used the RIP1-Tag2 (RT2) mouse model of islet cell carcinogenesis to identify a genetic locus that influences tumor progression to an invasive growth state. RT2 mice inbred into the C57BL/6 (B6) background de...

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Bibliographic Details
Main Authors: Chun, Matthew G. H., Mao, Jian-Hua, Chiu, Christopher W., Balmain, Allan, Hanahan, Douglas
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2010
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2951397/
https://ncbi.nlm.nih.gov/pubmed/20855625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1012705107
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