Stathmin and Interfacial Microtubule Inhibitors Recognize a Naturally Curved Conformation of Tubulin Dimers

Tubulin is able to switch between a straight microtubule-like structure and a curved structure in complex with the stathmin-like domain of the RB3 protein (T(2)RB3). GTP hydrolysis following microtubule assembly induces protofilament curvature and disassembly. The conformation of the labile tubulin...

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Main Authors: Barbier, Pascale, Dorléans, Audrey, Devred, Francois, Sanz, Laura, Allegro, Diane, Alfonso, Carlos, Knossow, Marcel, Peyrot, Vincent, Andreu, Jose M.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2010
Teme:
Protein Structure and Folding
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2951239/
https://ncbi.nlm.nih.gov/pubmed/20675373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.141929
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