NMR Structure and Ion Channel Activity of the p7 Protein from Hepatitis C Virus

The small membrane protein p7 of hepatitis C virus forms oligomers and exhibits ion channel activity essential for virus infectivity. These viroporin features render p7 an attractive target for antiviral drug development. In this study, p7 from strain HCV-J (genotype 1b) was chemically synthesized a...

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Bibliographische Detailangaben
Hauptverfasser: Montserret, Roland, Saint, Nathalie, Vanbelle, Christophe, Salvay, Andrés Gerardo, Simorre, Jean-Pierre, Ebel, Christine, Sapay, Nicolas, Renisio, Jean-Guillaume, Böckmann, Anja, Steinmann, Eike, Pietschmann, Thomas, Dubuisson, Jean, Chipot, Christophe, Penin, François
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2010
Schlagworte:
Protein Structure and Folding
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2951219/
https://ncbi.nlm.nih.gov/pubmed/20667830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.122895
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