Estrogen Modification of Human Glutamate Dehydrogenases Is Linked to Enzyme Activation State

Mammalian glutamate dehydrogenase (GDH) is a housekeeping enzyme central to the metabolism of glutamate. Its activity is potently inhibited by GTP (IC(50) = 0.1–0.3 μm) and thought to be controlled by the need of the cell in ATP. Estrogens are also known to inhibit mammalian GDH, but at relatively h...

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Autors principals: Borompokas, Nikolas, Papachatzaki, Maria-Martha, Kanavouras, Konstantinos, Mastorodemos, Vasileios, Zaganas, Ioannis, Spanaki, Cleanthe, Plaitakis, Andreas
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2010
Matèries:
Enzymology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2951212/
https://ncbi.nlm.nih.gov/pubmed/20628048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.146084
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