Prolyl Isomerase Pin1 Regulates Transcription Factor LSF (TFCP2) by Facilitating Dephosphorylation at Two Serine-Proline Motifs

Transcription factor LSF is essential for cell cycle progression, being required for activating expression of the thymidylate synthase (Tyms) gene at the G1/S transition. We previously established that phosphorylation of LSF in early G1 at Ser-291 and Ser-309 inhibits its transcriptional activity an...

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Bibliografske podrobnosti
Main Authors: Saxena, Utsav H., Owens, Laura, Graham, Julie R., Cooper, Geoffrey M., Hansen, Ulla
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2010
Teme:
Signal Transduction
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2951187/
https://ncbi.nlm.nih.gov/pubmed/20682773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.078808
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