A Phase I Pharmacokinetic and Pharmacodynamic Correlative Study of the Antisense Bcl-2 Oligonucleotide G3139, in Combination with Carboplatin and Paclitaxel, in Patients with Advanced Solid Tumors

PURPOSE: This phase I trial assessed the safety and tolerability of G3139 when administered in combination with carboplatin and paclitaxel chemotherapy. The effect of G3139 treatment on Bcl-2 expression in peripheral blood mononuclear cells (PBMC) and paired tumor biopsies was also determined. EXPER...

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Autors principals: Liu, Glenn, Kolesar, Jill, McNeel, Douglas G., Leith, Catherine, Schell, Kathy, Eickhoff, Jens, Lee, Fred, Traynor, Anne, Marnocha, Rebecca, Alberti, Dona, Zwiebel, James, Wilding, George
Format: Artigo
Idioma:Inglês
Publicat: 2008
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2950700/
https://ncbi.nlm.nih.gov/pubmed/18451239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-07-1490
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