Intracellular activation of digestive zymogens in rat pancreatic acini. Stimulation by high doses of cholecystokinin.

The mechanism by which digestive zymogens become activated during acute pancreatitis remains poorly understood. Given the ability for cholecystokinin (CCK) to induce pancreatitis in vivo, the effects of high dose CCK on preparations of isolated pancreatic acini were examined. Using an immunologic te...

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Pubblicato in:	J Clin Invest
Autori principali:	Leach, S D, Modlin, I M, Scheele, G A, Gorelick, F S
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 1991
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC295064/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1985109/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI114995
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