Important Role for the Murid Herpesvirus 4 Ribonucleotide Reductase Large Subunit in Host Colonization via the Respiratory Tract

Viral enzymes that process small molecules provide potential chemotherapeutic targets. A key constraint—the replicative potential of spontaneous enzyme mutants—has been hard to define with human gammaherpesviruses because of their narrow species tropisms. Here, we disrupted the murid herpesvirus 4 (...

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Bibliographic Details
Main Authors: Gill, Michael B., May, Janet S., Colaco, Susanna, Stevenson, Philip G.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2010
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2950598/
https://ncbi.nlm.nih.gov/pubmed/20668075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00828-10
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