A Single-Amino-Acid Substitution in Herpes Simplex Virus 1 Envelope Glycoprotein B at a Site Required for Binding to the Paired Immunoglobulin-Like Type 2 Receptor α (PILRα) Abrogates PILRα-Dependent Viral Entry and Reduces Pathogenesis

Paired immunoglobulin-like type 2 receptor α (PILRα) is a herpes simplex virus 1 (HSV-1) entry receptor that associates with O-glycans on HSV-1 envelope glycoprotein B (gB). Two threonine residues (Thr-53 and Thr-480) in gB, which are required for the addition of the principal gB O-glycans, are esse...

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Autores principales: Arii, Jun, Wang, Jing, Morimoto, Tomomi, Suenaga, Tadahiro, Akashi, Hiroomi, Arase, Hisashi, Kawaguchi, Yasushi
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology (ASM) 2010
Materias:
Virus-Cell Interactions
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2950593/
https://ncbi.nlm.nih.gov/pubmed/20686018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01166-10
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