Decreased Gs alpha mRNA levels accompany the fall in Gs and adenylyl cyclase activities in compensated left ventricular hypertrophy. In heart failure, only the impairment in adenylyl cyclase activation progresses.

We have previously reported that there is a global reduction in adenylyl cyclase associated with a decrement in Gs functional activity in cardiac sarcolemma from animals with pressure overload-induced hypertrophy and heart failure. This study was performed to determine whether hypertrophy alone in t...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Clin Invest
Auteurs principaux: Chen, L A, Vatner, D E, Vatner, S F, Hittinger, L, Homcy, C J
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 1991
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC295048/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1824633/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI114985
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