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Sigma-2: Multiple sequence alignment of non-coding DNA via an evolutionary model

BACKGROUND: While most multiple sequence alignment programs expect that all or most of their input is known to be homologous, and penalise insertions and deletions, this is not a reasonable assumption for non-coding DNA, which is much less strongly conserved than protein-coding genes. Arguing that t...

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Detalhes bibliográficos
Main Authors: Jayaraman, Gayathri, Siddharthan, Rahul
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2949893/
https://ncbi.nlm.nih.gov/pubmed/20846408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-11-464
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