Cutaneous C-polymodal fibers lacking TRPV1 are sensitized to heat following inflammation, but fail to drive heat hyperalgesia in the absence of TPV1 containing C-heat fibers

BACKGROUND: Previous studies have shown that the TRPV1 ion channel plays a critical role in the development of heat hyperalgesia after inflammation, as inflamed TRPV1-/- mice develop mechanical allodynia but fail to develop thermal hyperalgesia. In order to further investigate the role of TRPV1, we...

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Detalhes bibliográficos
Main Authors: Koerber, H Richard, McIlwrath, Sabrina L, Lawson, Jeffrey J, Malin, Sacha A, Anderson, Collene E, Jankowski, Michael P, Davis, Brian M
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2949725/
https://ncbi.nlm.nih.gov/pubmed/20858240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1744-8069-6-58
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