Anti-tumor effects of retinoids combined with trastuzumab or tamoxifen in breast cancer cells: induction of apoptosis by retinoid/trastuzumab combinations

INTRODUCTION: HER2 and estrogen receptor (ER) are important in breast cancer and are therapeutic targets of trastuzumab (Herceptin) and tamoxifen, respectively. Retinoids inhibit breast cancer growth, and modulate signaling by HER2 and ER. We hypothesized that treatment with retinoids and simultaneo...

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Main Authors: Koay, Debbie C, Zerillo, Cynthia, Narayan, Murli, Harris, Lyndsay N, DiGiovanna, Michael P
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2010
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2949655/
https://ncbi.nlm.nih.gov/pubmed/20696059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr2625
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