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Molecular insight into the conformational dynamics of the Elongin BC complex and its interaction with HIV-1 Vif

The HIV-1 Virion infectivity factor (Vif) inhibits the innate viral immunity afforded by the APOBEC3 family of cytidine deaminases. Vif targets the APOBEC3 family for poly-ubiquitination and subsequent proteasomal degradation by linking the Elongin BC dependent ubiquitin ligase complex with the APOB...

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Detalhes bibliográficos
Main Authors: Marcsisin, Sean R., Engen, John R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2949506/
https://ncbi.nlm.nih.gov/pubmed/20728451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2010.08.026
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