Natural Killer Cell Tolerance Persists Despite Significant Reduction of Self MHC Class I on Normal Target Cells in Mice

BACKGROUND: A major group of murine inhibitory receptors on Natural Killer (NK) cells belong to the Ly49 receptor family and recognize MHC class I molecules. Infected or transformed target cells frequently downmodulate MHC class I molecules and can thus avoid CD8(+) T cell attack, but may at the sam...

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Detalhes bibliográficos
Main Authors: Brodin, Petter, Lakshmikanth, Tadepally, Mehr, Ramit, Johansson, Maria H., Duru, Adil Doganay, Achour, Adnane, Salmon-Divon, Mali, Kärre, Klas, Höglund, Petter, Johansson, Sofia
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2949391/
https://ncbi.nlm.nih.gov/pubmed/20957233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0013174
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