Alterations in nitric oxide and endothelin-1 bioactivity underlie cerebrovascular dysfunction in ApoE-deficient mice

Hypercholesterolemia is associated with decreased nitric oxide (NO) bioavailability and endothelial dysfunction, a phenomenon thought to have a major role in the altered cerebral blood flow evident in stroke. Therefore, strategies that increase endothelial NO production have potential utility. Vascu...

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Bibliographische Detailangaben
Hauptverfasser: Yamashiro, Kazuo, Milsom, Alexandra B, Duchene, Johan, Panayiotou, Catherine, Urabe, Takao, Hattori, Nobutaka, Ahluwalia, Amrita
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2010
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2949246/
https://ncbi.nlm.nih.gov/pubmed/20234380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2010.34
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