Inhibition of bradykinin receptor B1 protects mice from focal brain injury by reducing blood–brain barrier leakage and inflammation

Kinins are proinflammatory and vasoactive peptides that are released during tissue damage and may contribute to neuronal degeneration, inflammation, and edema formation after brain injury by acting on discrete bradykinin receptors, B1R and B2R. We studied the expression of B1R and B2R and the effect...

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Detalhes bibliográficos
Main Authors: Raslan, Furat, Schwarz, Tobias, Meuth, Sven G, Austinat, Madeleine, Bader, Michael, Renné, Thomas, Roosen, Klaus, Stoll, Guido, Sirén, Anna-Leena, Kleinschnitz, Christoph
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2010
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2949241/
https://ncbi.nlm.nih.gov/pubmed/20197781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2010.28
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