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Human recombinant tissue-plasminogen activator (alteplase): why not use the ‘human' dose for stroke studies in rats?
Since a pioneer work that has shown in vitro that the rat's fibrinolytic system is 10-fold less sensitive to recombinant tissue-plasminogen activator (rtPA) than the human system, most preclinical studies are performed with 10 instead of 0.9 mg/kg rtPA (the clinical dose in stroke patients). In...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2010
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2949192/ https://ncbi.nlm.nih.gov/pubmed/20216551 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2010.33 |
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