Matrix metalloproteinase-9 mediates hypoxia-induced vascular leakage in the brain via tight junction rearrangement

Blood–brain barrier (BBB) disruption, resulting from loss of tight junctions (TJ) and activation of matrix metalloproteinases (MMPs), is associated with edema formation in ischemic stroke. Cerebral edema develops in a phasic manner and consists of both vasogenic and cytotoxic components. Although it...

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Hlavní autoři: Bauer, Alexander T, Bürgers, Heinrich F, Rabie, Tamer, Marti, Hugo H
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2010
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2949161/
https://ncbi.nlm.nih.gov/pubmed/19997118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2009.248
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