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Increased brain microvascular MMP-9 and incidence of haemorrhagic transformation in obese mice after experimental stroke

Obesity is an independent risk factor for stroke and is associated with poorer outcome after stroke. We investigated whether this poorer outcome is related to brain microvascular disruption. Focal cerebral ischaemia was induced in lean or obese (ob/ob) mice by transient middle cerebral artery occlus...

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Autori principali: McColl, Barry W, Rose, Nicola, Robson, Fiona H, Rothwell, Nancy J, Lawrence, Catherine B
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2949124/
https://ncbi.nlm.nih.gov/pubmed/19826431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2009.217
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