Design and characterization of the first peptidomimetic molecule that prevents acidification-induced closure of cardiac gap junctions

BACKGROUND: Gap junctions are potential targets for pharmacological intervention. We have previously developed a series of peptide sequences that prevent closure of Cx43 channels, bind to cardiac Cx43 and prevent acidification-induced uncoupling of cardiac gap junctions. OBJECTIVE: We aimed to ident...

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Hlavní autoři: Verma, Vandana, Larsen, Bjarne Due, Coombs, Wanda, Lin, Xianming, Sarrou, Eliana, Taffet, Steven M., Delmar, Mario
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2948861/
https://ncbi.nlm.nih.gov/pubmed/20601149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.hrthm.2010.06.028
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