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Protective immune responses elicited by immunization with a chimeric blood-stage malaria vaccine persist but are not boosted by Plasmodium yoelii challenge infection

An efficacious malaria vaccine remains elusive despite concerted efforts. Using the Plasmodium yoelii murine model, we previously reported that immunization with the C-terminal 19 kDa domain of merozoite surface protein 1 (MSP1(19)) fused to full-length MSP8 protected against lethal P. yoelii 17XL,...

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Autors principals: Alaro, James R., Lynch, Michele M., Burns, James M.
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2948860/
https://ncbi.nlm.nih.gov/pubmed/20709001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2010.08.018
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