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Laminar Shear Stress Modulates Phosphorylation and Localization of RNA Polymerase II on the Endothelial Nitric Oxide Synthase Gene

OBJECTIVE: In endothelial cells exposed to unidirectional, laminar shear stress (LSS), eNOS transcription, mRNA stability, and protein levels are enhanced. We have previously demonstrated that these changes are associated with increased 3′ polyadenylation of eNOS mRNA. Here, we investigated the effe...

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Autori principali: Moore, Jeffrey P., Weber, Martina, Searles, Charles D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2948754/
https://ncbi.nlm.nih.gov/pubmed/20167666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.109.199554
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