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SH3BP2 Mutations Potentiate Osteoclastogenesis via PLCγ

To determine the mechanism for the increased osteoclastogenesis in the jaw of cherubism patients with SH3BP2 mutations we evaluated the effect of mutant compared to wild-type SH3BP2 on activation of osteoclast signaling pathways. Indeed mutant forms of SH3BP2 do induce greater osteoclastogenesis. He...

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Bibliografiske detaljer
Main Authors: Lietman, Steven A., Yin, Lihong, Levine, Michael A.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2948751/
https://ncbi.nlm.nih.gov/pubmed/20872577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jor.21164
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