Platelet-derived growth factor enhances platelet recovery in a murine model of radiation-induced thrombocytopenia and reduces apoptosis in megakaryocytes via its receptors and the PI3-k/Akt pathway

BACKGROUND: Platelet-derived growth factor is involved in the regulation of hematopoiesis. Imatinib mesylate, a platelet-derived growth factor receptor inhibitor, induces thrombocytopenia in a significant proportion of patients with chronic myeloid leukemia. Although our previous studies showed that...

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Detalhes bibliográficos
Main Authors: Ye, Jie Yu, Chan, Godfrey Chi Fung, Qiao, Liang, Lian, Qizhou, Meng, Fan Yi, Luo, Xue Qun, Khachigian, Levon M., Ma, Ming, Deng, Ruixia, Chen, Jian Liang, Chong, Beng H., Yang, Mo
Formato: Artigo
Idioma:Inglês
Publicado em: Ferrata Storti Foundation 2010
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2948101/
https://ncbi.nlm.nih.gov/pubmed/20562316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2009.020958
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