Prostate Apoptosis Response-4 Is Expressed in Normal Cholangiocytes, Is Down-Regulated in Human Cholangiocarcinoma, and Promotes Apoptosis of Neoplastic Cholangiocytes When Induced Pharmacologically

Prostate apoptosis response-4 (Par-4) is a tumor suppressor protein that sensitizes cells to apoptosis; therefore, Par-4 modulation has therapeutic potential. No data currently exist on Par-4 expression in cholangiocarcinoma (CCA). We evaluated the expression of Par-4 in normal and neoplastic cholan...

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Autors principals: Franchitto, Antonio, Torrice, Alessia, Semeraro, Rossella, Napoli, Cristina, Nuzzo, Gennaro, Giuliante, Felice, Alpini, Gianfranco, Carpino, Guido, Berloco, Pasquale Bartolomeo, Izzo, Luciano, Bolognese, Antonio, Onori, Paolo, Renzi, Anastasia, Cantafora, Alfredo, Gaudio, Eugenio, Alvaro, Domenico
Format: Artigo
Idioma:Inglês
Publicat: American Society for Investigative Pathology 2010
Matèries:
Regular Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2947274/
https://ncbi.nlm.nih.gov/pubmed/20724592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.091171
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