Therapeutic Treg expansion in mice by TNFRSF25 prevents allergic lung inflammation

TNF receptor superfamily member 25 (TNFRSF25; also known as DR3, and referred to herein as TNFR25) is constitutively and highly expressed by CD4(+)FoxP3(+) Tregs. However, its function on these cells has not been determined. Here we used a TNFR25-specific agonistic monoclonal antibody, 4C12, to stud...

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Autori principali: Schreiber, Taylor H., Wolf, Dietlinde, Tsai, Matthew S., Chirinos, Jackie, Deyev, Vadim V., Gonzalez, Louis, Malek, Thomas R., Levy, Robert B., Podack, Eckhard R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2010
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2947231/
https://ncbi.nlm.nih.gov/pubmed/20890040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI42933
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