Integration of a Notch-dependent mesenchymal gene program and Bmp2-driven cell invasiveness regulates murine cardiac valve formation

Cardiac valve formation is crucial for embryonic and adult heart function. Valve malformations constitute the most common congenital cardiac defect, but little is known about the molecular mechanisms regulating valve formation and homeostasis. Here, we show that endocardial Notch1 and myocardial Bmp...

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Detalhes bibliográficos
Main Authors: Luna-Zurita, Luis, Prados, Belén, Grego-Bessa, Joaquim, Luxán, Guillermo, del Monte, Gonzalo, Benguría, Alberto, Adams, Ralf H., Pérez-Pomares, José María, de la Pompa, José Luis
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2947227/
https://ncbi.nlm.nih.gov/pubmed/20890042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI42666
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