Replacing adenoviral vector HVR1 with a malaria B cell epitope improves immunogenicity and circumvents preexisting immunity to adenovirus in mice

Although adenovirus (Ad) has been regarded as an excellent vaccine vector, there are 2 major drawbacks to using this platform: (a) Ad-based vaccines induce a relatively weak humoral response against encoded transgenes, and (b) preexisting immunity to Ad is highly prevalent among the general populati...

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Detaylı Bibliyografya
Asıl Yazarlar: Shiratsuchi, Takayuki, Rai, Urvashi, Krause, Anja, Worgall, Stefan, Tsuji, Moriya
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Clinical Investigation 2010
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2947213/
https://ncbi.nlm.nih.gov/pubmed/20811151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI39812
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