Folylpolyglutamate Synthetase Gene Transcription is Regulated by a Multiprotein Complex that Binds the TEL-AML1 Fusion in Acute Lymphoblastic Leukemia

Acute Lymphoblastic Leukemia (ALL) non-random fusions influence clinical outcome and alter the accumulation of MTX-PGs in vivo. Analysis of primary ALL samples uncovered subtype-specific patterns of folate gene expression. Using an FPGS-luciferase reporter gene assay, we determined that E2A-PBX1 and...

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Bibliographic Details
Main Authors: Leclerc, Guy J., Sanderson, Christopher, Hunger, Stephen, Devidas, Meenakshi, Barredo, Julio C.
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2946984/
https://ncbi.nlm.nih.gov/pubmed/20538338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.leukres.2010.05.012
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