GD3 Accumulation in Cell Surface Lipid Rafts Prior to Mitochondrial Targeting Contributes to Amyloid-β-induced Apoptosis

Neuronal apoptosis induced by amyloid β-peptide (Aβ) plays an important role in the pathophysiology of Alzheimer's disease (AD). However, the molecular mechanism underlying Aβ-induced apoptosis remains undetermined. The disialoganglioside GD3 involves ceramide-, Fas- and TNF-α-mediated apoptosi...

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Detalhes bibliográficos
Main Authors: Kim, Jong-Kook, Kim, Sang-Ho, Cho, Hee-Young, Shin, Hee-Soo, Sung, Hye-Ryen, Jung, Jin-Ran, Quan, Mei-Lian, Jiang, Dong-Hong, Bae, Hae-Rahn
Formato: Artigo
Idioma:Inglês
Publicado em: The Korean Academy of Medical Sciences 2010
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2946661/
https://ncbi.nlm.nih.gov/pubmed/20890432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3346/jkms.2010.25.10.1492
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