Efficient Transduction of Feline Neural Progenitor Cells for Delivery of Glial Cell Line-Derived Neurotrophic Factor Using a Feline Immunodeficiency Virus-Based Lentiviral Construct

Work has shown that stem cell transplantation can rescue or replace neurons in models of retinal degenerative disease. Neural progenitor cells (NPCs) modified to overexpress neurotrophic factors are one means of providing sustained delivery of therapeutic gene products in vivo. To develop a nonroden...

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Main Authors: You, X. Joann, Gu, Ping, Wang, Jinmei, Song, Tianran, Yang, Jing, Liew, Chee Gee, Klassen, Henry
Format: Artigo
Jezik:Inglês
Izdano: Hindawi Publishing Corporation 2011
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2946610/
https://ncbi.nlm.nih.gov/pubmed/20936061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2011/378965
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