A TOMM40 variable-length polymorphism predicts the age of late-onset Alzheimer's disease

The ɛ4 allele of the apolipoprotein E (APOE) gene is currently the strongest and most highly replicated genetic factor for risk and age of onset of late-onset Alzheimer's disease (LOAD). Using phylogenetic analysis, we have identified a polymorphic poly-T variant, rs10524523, in the translocase...

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Detalhes bibliográficos
Main Authors: Roses, A D, Lutz, M W, Amrine-Madsen, H, Saunders, A M, Crenshaw, D G, Sundseth, S S, Huentelman, M J, Welsh-Bohmer, K A, Reiman, E M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2010
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2946560/
https://ncbi.nlm.nih.gov/pubmed/20029386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/tpj.2009.69
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